Sleep medicine, built for the modern era

Today, Zest is launching the world’s first 2-in-1 melatonin and caffeine capsule: the Sleep Reset Pill. It is the first product of its kind designed to help reset your sleep schedule and support your circadian rhythm.* We are also announcing Zest RX: clinician-led care for sleep and wakefulness.

At Zest, our goal has always been to build sleep care around how the body actually keeps time. We’ve spent years developing our dual-release matrix technology with Swiss neuroscientists, pharmaceutical scientists and sleep doctors, refining it through millions of nights of formulation and testing, and putting our timed-release technology through a peer-reviewed clinical trial. We hold ourselves to the standard of medicine: every product is designed with safety and effectiveness in mind, backed by evidence, and honest about what it does and doesn’t do.

Sleep medicine is stuck in the past. The most prescribed sleep drugs are decades old, often addictive, and sedate you instead of letting you truly rest. Meanwhile, your body runs on a 24-hour clock, and modern life keeps pulling it out of sync: artificial light tricks your brain into staying up, late-night scrolling steals your sleep, caffeine hits too late, and jet lag, shift work and weekend catch-up sleep keep moving your schedule. Yet nearly every sleep product is about falling asleep or sleeping “better.” Almost none are about sleeping on time, even though regularity may matter more: in a study of 60,000 adults, the most regular sleepers had a 20–48% lower risk of early death than the least regular.¹

Your circadian rhythm keeps time with two hormones: melatonin at night, cortisol in the morning. The Sleep Reset Pill follows the same rhythm, in one capsule. Our dual-release matrix technology releases 0.5 mg of melatonin through the first half of the night, your body’s cue to sleep, then 80 mg of caffeine in the morning, timed for when you wake.* Take one before bed. That’s the whole routine.

Zest RX is designed for those who want a more personalised clinical plan for sleep and wakefulness issues. After an online consultation, a licensed provider can prescribe from a new generation of treatments, designed with safety and effectiveness in mind: modern medications and peptide therapies, each compounded and dosed for you, and shipped to your door.

We’re excited to finally bring sleep medicine into the 21st century. Your best mornings start the night before.

¹ Windred et al., Sleep (2024). Zest’s timed-release technology: Dornbierer et al., Scientific Reports (2021).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.